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HypersensitivityA case study suggests cell-mediated immunity to allopurinol and oxypurinol is involved in allopurinol-induced hypersensitivity reactions. There are no data with amoxicillin and clavulanate potassium tablets and allopurinol administered concurrently. At least two cases of allopurinol-induced aseptic meningitis have also been reported. Allopurinol is in the following drug classes: antigout agents, antihyperuricemic agents. GastrointestinalA first of a kind case report, elevations in pancreatic exocrine enzyme level, new-onset type 1 diabetes mellitus, and allopurinol hypersensitivity syndrome have been reported in a 58-year-old Cambodian female. A 43-year-old female with chronic kidney disease developed fever, generalized morbilliform rash, leukocytosis with marked eosinophilia, and hepatic dysfunction 3 weeks after starting allopurinol therapy (300 mg/day for 3 days followed by 200 mg/day) for hyperuricemia and arthritis. At least 3 cases of allopurinol hypersensitivity syndrome have also been reported. See the package inserts or Acetazolamide in Carbonic Anhydrase Inhibitors (Systemic) , Allopurinol (Systemic) , and/or Potassium Citrate in Citrates (Systemic) for specific dosing guidelines for use of these products. There is a case report of a patient with no history of psychiatric disease whose allopurinol-associated catatonia, rash, and fever responded to steroids.
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